Which bactericidal preservatives can replace isothiazolinone in daily chemical products?
Isothiazolinone is also widely used in the field of daily chemical, widely used in cosmetics, shampoo and conditioner, hand sanitizer and body wash and other products, to prevent products from bacterial and microbial infestation, so as to ensure the quality and stability of cosmetics, can effectively inhibit the reproduction of bacteria, maintain the freshness and quality of products, so the addition of isothiazolinone can enhance the anti-corrosion of products, Maintain the long-term durability of the product
The maximum allowable concentration of isothiazolinone in cosmetic use is 0.0015% in China's "Cosmetic Safety Technical Specification 2015", of which the elutriation products cannot be used at the same time with methyl isothiazolinone. When the amount of isothiazolinone is lower, it often does not have an anti-corrosion effect, especially in products with serious bacterial contamination. Which bactericide products can replace isothiazolinone for system anticorrosion?
1) DMDMDH. DMDMH (1, 3-dihydroxymethyl-5, 5-dimethylhyne, CAS NO: 6440-58-0), commonly known as hydantoyl urea, is a formaldehyde slow release fungicide. Formaldehyde can penetrate the cell membrane without any barrier into the interior of the cell, and formaldehyde can alkalize the amino group, sulfhydryl group and purine base of the protein, denaturating the protein, and eventually leading to the death of the bacteria. Although this type of preservative releases formaldehyde, it is safe because it is released slowly. Also in the cosmetic safety technical specifications, the regulations allow the maximum addition of 0.6%, which is more commonly used in washing products.
2) IPBC10. IPBC (butyl iodopropylcarbamate, CAS: 55406-53-6), a halogen bactericide, can slowly release iodine ions in the system, which has a toxic effect on microorganisms, and very low doses of iodine ions will also have a strong toxic effect on mold. In our regulations, the maximum allowable concentration of eluvial products is 0.02%{Note: shall not be used in products for children under three years of age (except bath products and shampoos); Do not use in lip products)}, and the maximum allowable concentration of resident products is 0.01% (do not use in products for children under three years of age; Do not use on lip products; Do not use in body creams and body creams).
3) phenoxyethanol PE. Phenoxyethanol is also often used in the anti-corrosion of daily chemical products, and the use of a very wide range of high concentrations of alcohols (phenoxyethanol purity is higher than 99%) can destroy the integrity of cell membranes, make cell contents leak out, and quickly act on microorganisms; Slight skin irritation, no damage. The inhibitory effect of 0.5-1.0% was better, especially on pseudomonas aeruginosa. The concentration above 0.3% has a strong thermal sensation in the mask. Suitable for use with antibacterial synergists. China, the European Union, Japan, the United States regulations stipulate that the maximum concentration of phenoxyethanol is 1%.
4) Parabens. Parabens have been used as bacteriostatic agents for nearly 100 years and have been widely used. Because of its wide antibacterial spectrum and low irritation to the skin, it has a relatively high degree of recognition in cosmetics. The mechanism of action is that such molecular structures can enter the microbial cell membrane and change its permeability, resulting in the leakage of intracellular lysates, and the inactivation of ion transfer proteins in the cell membrane, resulting in the loss of the energy gradient coupled with them. In cosmetics called hydroxybenzoyl, B, C, butyl ester and its salt, the most widely used, of which hydroxyphenyl methyl ester (MP), hydroxyphenyl propyl ester (PP) is a typical representative.
