Comparison of commonly used preservatives in in vitro diagnostic reagents
The stability of in vitro diagnostic reagents is the key to restricting the marketization of products. There have been a number of patents on preservatives for in vitro diagnostic reagents abroad, but the domestic is still in the exploration stage. With the continuous development of in vitro diagnostic reagents, the requirements for preservatives will become higher and higher, and preservatives that are highly toxic to the human body and the environment, such as thimerosal and sodium azide, will gradually be replaced. In the future, preservatives will develop in the direction of broad spectrum, high efficiency, low toxicity and environmental protection.
preservative | Principle of action | advantage | shortcoming |
| Sodium Azide | Inhibit enzyme activity | The effect is remarkable | Very toxic, inhibits a variety of enzymes |
| Thimerosal | Inhibit enzyme activity | Broad spectrum, strong antibacterial power | Potentially harmful |
| Gentamicin | Binding to ribosomes | Broad antibacterial spectrum | Prone to drug resistance |
| Isothiazolinones | Inhibit enzyme activity | Efficient and stable | Have a certain irritation and sensitization |
