About Bropol (Brominol, BNPD, Bronopol) antiseptic preservatives, you read this article is enough(一）
Pure product is white to light yellow powder or crystal, odorless and tasteless. Melting point 118℃. The solubility in water is 25g/100g(25℃); Insoluble in oil, solubility in oil is 0.5g/100g(25℃). Low oil/water distribution coefficient. Aqueous solutions decompose slowly when alkaline. Not compatible with certain metals (such as aluminum). This product is unstable under high temperature and alkaline conditions (pH greater than 8) and turns brown under light.
Brobuble is a bromo-nitroalcohol broad spectrum fungicide, with high bactericidal activity and very low concentration and wide range of use, no irritation to human skin, no sensitization reaction, is one of the cosmetic preservatives approved for use in the United States.
Three antibacterial mechanisms
(1) The antibacterial activity comes from the electron-deficient oxidizing bromine atoms in the molecule. The mechanism of antibacterial action is that bromine atoms oxidize the mercaptol group on the surface of bacterial cell membrane, making it become a disulphide compound, producing a large bulge in the cell wall, causing the cell wall to break, the internal soluble matter to flow out and kill bacteria;
(2) Another possible pathway is the release of activated bromine, which combines with cell membrane proteins to form nitrogen-bromine compounds, thus interfering with cell metabolism and finally causing bacterial death;
(3) The formaldehyde released during broble decomposition can also coagulate bacterial proteins, thus playing a bactericidal role.
Anti-mildew and antibacterial effect
Bropol is a broad-spectrum antibacterial agent, which mainly oxidizes sulfhydryl groups in bacterial enzymes, inhibits the activity of dehydrogenase and causes irreversible damage to cell membranes. It is highly active against gram-negative bacteria, especially Pseudomonas aeruginosa. Broball is more effective against bacteria than molds and yeasts. This compound is bactericidal over a wide pH range and is not affected by cationic, anionic surfactants or proteins
Influencing factors of microbial effect
Broble has a broad spectrum of antibacterial action, at 25ppm concentration can inhibit the growth of most bacteria, especially for gram-negative bacteria, including Pseudomonas aeruginosa also has a good inhibitory effect. But the inhibition effect on mold and yeast is not so good.
There are several factors that affect the corrosion resistance of Broble:
First, the use of concentration
The higher the concentration of broble, the better the anti-corrosion effect, and the fungicide must reach a certain amount to have the effect of killing or inhibiting microorganisms.
Second, acid and alkali
